By Andrew Eisen, Charles Krieger
Amyotrophic Lateral Sclerosis, another way often called Lou Gehrig's sickness, is one of many degenerative ailments of the getting older worried method. this article smartly synthesizes the hot explosion of study into this actual to build an in depth and finished assessment. Drs. Eisen and Krieger deliver their study services and wide medical event to supply this useful and thought-provoking account. Chapters hide the epidemiology, molecular biology, and pathophysiology of ALS, in addition to matters pertinent to medical overview and care.
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Extra resources for Amyotrophic Lateral Sclerosis: A Synthesis of Research and Clinical Practice
2). Even though disease duration in young women also appears longer than in other age groups, the numbers were too few for the difference to reach statistical significance. 2 shows that the differences in survival are significantly affected by age but not by sex. 02). 0001). 001). 008). 14 Epidemiological considerations Risk factors for developing ALS Age and gender are the only indisputable risk factors for sporadic ALS (Nelson, 1996). With the growth of an ageing population, it can be predicted that the incidence of ALS and other neurodegenerative diseases will significantly increase.
One of the authors (AE) visited Guam in 1989 and performed physiological studies in patients with ALS. , 1993c). This does not necessarily indicate that ALS on Guam has a longer duration; it is more likely that the surviving patients are those who had a more slowly progressive disease. Also, as pointed out above, the disease in the western Pacific is probably fundamentally different from sporadic ALS. New cases on the island seem to occur with equal frequency in all of the ethnic populations of Guam, suggesting that ALS developing at this time is more like sporadic ALS.
0). Other industrial exposures that showed large, non-significant differences included paint or pigment manufacturing, the petroleum industry, the printing industry and shipbuilding. An unproven, but potential, common candidate toxin for some of these could be lead or mercury. Heavy metals The possibility that heavy metal intoxication may be a risk factor for ALS has been raised for over half a century. Many elements have, at one time or another, been considered as aetiopathogenic candidates for ALS (Mitchell, 1997).
Amyotrophic Lateral Sclerosis: A Synthesis of Research and Clinical Practice by Andrew Eisen, Charles Krieger