By Philip N Patsalos
This up-to-date 3rd version of a profitable publication is an outline of either pharmacokinetic and pharmacodynamic antiepileptic drug (AED) interactions, together with info of the significance and mechanism of interactions, and likewise of drug combos that aren't linked to interactions and for that reason might be coprescribed with no undue drawback. awarded in alphabetical order and through drug type, drug interactions that ensue among AEDs and likewise among AEDs and non-AEDs are defined in 3 sections: Drug interactions among AEDs; Drug interactions among AEDs and non-AED medications: Interactions affecting AEDs; Drug interactions among AEDs and non-AED medicines: Interactions tormented by AEDs.
Antiepileptic Drug Interactions: A medical consultant, third Edition with its transparent, concise and unambiguous content material will
allow physicians and allied future health pros to make extra rational offerings while AED polytherapy regimens are indicated. there's consistently a decision and heading off hugely interacting medicines and selecting drug mixtures which are minimally interacting or don't engage could be the aim in treating sufferers with epilepsy. This booklet presents all of the invaluable details in an effort to enable this aim to be accomplished and, if important, to help powerful administration of AED interactions.
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Additional resources for Antiepileptic Drug Interactions: A Clinical Guide
Theoretically, a pharmacokinetic interaction would not be anticipated The interaction has not been investigated. Theoretically, a pharmacokinetic interaction would not be anticipated The interaction has not been investigated. Theoretically, a pharmacokinetic interaction would not be anticipated Interactions with AEDs Eslicarbazepine acetate Ethosuximide Felbamate Gabapentin Lacosamide Lamotrigine Levetiracetam Methsuximide Oxcarbazepine Perampanel Phenobarbital Phenytoin Piracetam Pregabalin Primidone Retigabine Rufinamide Stiripentol Sulthiame Tiagabine Topiramate 9 The interaction has not been investigated.
32. Spina E, Arena S, Scordo MG, Fazio A, Pisan F, Perucca E. Elevation of plasma carbamazepine concentrations by ketoconazole in patients with epilepsy. Ther Drug Monit. 1997;19:535–8. 33. 33. Tucker RM, Denning DW, Hanson LH, Rinaldi MG, Graybill JR, Sharkey PK, Pappagianis D, Stevens DA. Interaction of azoles with rifampin, phenytoin, and carbamazepine: in vitro and clinical observations. Clin Infect Dis. 1992;14:165–74. 34. Miller RR, Porter J, Greenblatt DJ. Clinical importance of the interaction of phenytoin and isoniazid.
Furthermore, in order to be able to anticipate the possible clinical relevance of an interaction, it is important to determine the relative contribution of the metabolic pathway(s) being inhibited or induced to the overall elimination of the drug. In some cases, a single metabolic reaction may involve multiple isoforms or different enzyme systems, while in other cases all the metabolic reactions of a drug are catalyzed by a single enzyme. The metabolism (S-oxidation) of 10-(N,Ndimethylaminoalkyl) phenothiazines is an example of the first scenario in which numerous CYP isoforms, including CYP2A6, CYP2C8, and CYP2D6, are involved in its metabolism.
Antiepileptic Drug Interactions: A Clinical Guide by Philip N Patsalos