By Qing-Ping Zeng
This booklet discusses either the priceless and destructive features of NO in biology and drugs, and likewise introduces the rising discovery of artemisinin in antitumor, antibacterial an infection, anti-inflammation, and antiaging contexts. In 1992 nitric oxide (NO) used to be voted “Molecule of the yr” via technology journal, and the invention of its physiological roles has ended in Nobel Prize-winning paintings in neuroscience, body structure and immunology. The e-book explains why we should always keep a steady-state NO point that's derived from neuronal or epithelial NO synthase, and stay away from the super excessive NO point because of inducible NO synthase. The e-book bargains a useful source for scientific chemists, clinicians, biologists and all these attracted to overall healthiness and disease.
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Extra resources for Artemisinin and Nitric Oxide: Mechanisms and Implications in Disease and Health
2007), and in numerous disease-affected tissues (Buddi et al. 2002). The 3NT-mediated nitrosative stress may participate in the pathogenesis of diabetes and other aging-related disorders (Pacher et al. 2005). Another important reaction is the alkylation of transition metal ions, which involves the binding of NO to a transition metal ion. The typical case is alkylating the prosthetic heme in hemoproteins, in which NO might behave as either an inhibitor or an activator to affect a homoprotein’s function (van Faassen and Vanin 2004).
3 Discussion It has been reported that approximately 5–18 % of ART can bind to hemoproteins such as hemoglobin, but does not react with heme-free globins (Meshnick et al. 1991). Among versatile hemoproteins, ART’s targets for exerting antitumor activity are currently unidentified. Because NOS was previously proved a cytochrome P450-like hemoprotein (Chinje and Stratford 1991), we planed to examine whether the formation of ART-heme adducts might be correlated with the elevation of NO levels as well as whether they would accompany with the elevation or decline of survival rates in HepG2.
It is also thought that when the peroxide lactone of ART comes into contact with a high titer of iron commonly seen in cancerous cells, ART might become unstable and release ROS. Recent pharmacological evidence has demonstrated that dihydroartemisinin targets human metastatic melanoma cells and induces the mitochondrial apoptosis (Cabello et al. 2011). 5 Conclusions ART, a sesquiterpene lactone with a unique endoperoxide bridge, is extracted from the medicinal plant species A. annua L. Although ART was originally discovered as a malaria-killing drug, it actually exhibits a wide range of therapeutic potentials, especially in antitumor.
Artemisinin and Nitric Oxide: Mechanisms and Implications in Disease and Health by Qing-Ping Zeng